During cell migration and polarization, numerous signal transduction and cytoskeletal
components self-organize to generate localized protrusions. Although biochemical and …

Phosphoinositide 3-kinases regulate many cellular functions, including migration, growth,
proliferation, and cell survival. Early studies equated the inhibition of Class I PI3Ks with loss …

The development of anti-aging drugs is challenged by both the apparent complexity of the
physiological mechanisms involved in aging and the likelihood that many of these …

The ability to fight or flee from a threat relies on an acute adrenergic surge that augments
cardiac output, which is dependent on increased cardiac contractility and heart rate. This …

NLRP3 is an inflammasome seeding pattern recognition receptor activated in response to
multiple danger signals which perturb intracellular homeostasis. Electrostatic interactions …

Organelles play significant roles in mediating communication between and within cells.
Furthermore, organelle failure would affect cellular homeostasis and result in a variety of …

In many animal species, the oocyte meiotic spindle, which is required for chromosome
segregation, forms without centrosomes. In some systems, Ran-GEF on chromatin initiates …

Mass spectrometry imaging (MSI) is used for visualizing the distribution of components in
solid samples, such as biological tissues, and requires a technique to ionize the …

Many cellular functions are regulated by cell surface charges, such as intercellular signaling
and metabolism. Noninvasive measurement of surface charge distribution of a single cell …

Giant unilamellar vesicles (GUVs) are micrometer-scale minimal cellular mimics that are
useful for bottom-up synthetic biology and drug delivery. Unlike assembly in low-salt …