Protein–protein interactions (PPIs) are involved at all levels of cellular organization, thus
making the development of PPI inhibitors extremely valuable. The identification of selective …

Inhibition of protein–protein interactions (PPIs) represents a significant challenge because it
is unclear how they can be effectively and selectively targeted using small molecules …

Among the strategies that can lead to the discovery of new drugs, the identification and use
of privileged structures, molecular fragments that are able to interact with more than one …

The myeloid leukemia cell differentiation protein (Mcl-1) is an anti-apoptotic protein of the B-
cell lymphoma 2 (Bcl-2) family, which regulates cellular apoptosis. Mcl-1 expression plays a …

Although many cellular processes depend upon enzymatic reactions, protein–protein
interactions (PPIs) mediate a large number of important regulatory pathways and thus play a …

Many biological processes are regulated by protein–protein interactions (PPIs) and as such
their misregulation can cause a multitude of diseases. Often the interactions between large …

Protein–protein interactions (PPI) are vital in modulating biochemical pathways in many
biological processes. Inhibiting PPI is a tremendously important diagnostic and therapeutic …

Protein–protein interactions (PPIs) are tremendously important for the function of many
biological processes. However, because of the structure of many protein–protein interfaces …

Target-focused compound libraries are collections of compounds which are designed to
interact with an individual protein target or, frequently, a family of related targets (such as …

Connects fundamental knowledge of multivalent interactions with current practice and state-
of-the-art applications Multivalency is a widespread phenomenon, with applications …