Redox post-translational modifications are derived from fluctuations in the redox potential
and modulate protein function, localization, activity and structure. Amongst the oxidative …

Significance: Glutathione (GSH) represents the most abundant and the main antioxidant in
the body with important functions in the brain related to Alzheimer's disease (AD). Recent …

Mitochondrial impairment as evidenced by decline in adenosine 5′-triphosphate (ATP) is
associated with oxidative stress in Alzheimer's disease neuropathology and suggests that …

Sažetak Glutathione (γ-glutamyl-cysteinyl-glycine) is an intracellular thiol molecule and a
potent antioxidant that participates in the toxic metabolism phase II biotransformation of …

8‐Hydroxy‐2′‐deoxyguanosine (8‐OHdG) is one of the major forms of oxidative DNA
damage, and is commonly analyzed as an excellent marker of DNA lesions. The purpose of …

Alzheimer's disease (AD) is a debilitating dementia with complex pathophysiological
alterations including modifications to endogenous cysteine. S-nitrosylation (SNO) is a well …

Cysteine is a highly reactive amino acid and is subject to a variety of reversible post‐
translational modifications (PTMs), including nitrosylation, glutathionylation, palmitoylation …

Microglia are resident macrophages in the central nervous system, whose participation
against exogenous injuries and infections is mainly marked by an immediate release of …

Increased production of hydroxyl radical is the main source of oxidative damage in
mammalian DNA that accumulates in Alzheimer's disease (AD). Reactive oxygen species …

Abstract Glutaredoxin1 (GRX1) is a glutathione (GSH)-dependent thiol oxidoreductase. The
GRX1/GSH system is important for the protection of proteins from oxidative damage and in …