Alzheimer's disease (AD) is traditionally viewed through the lens of the amyloid cascade
hypothesis, implicating amyloid-beta and tau protein aggregates as the main pathological …

The widely-accepted hallmark pathology of Parkinson's disease (PD) is the presence of
Lewy bodies with characteristic abnormal aggregated α-synuclein (αSyn). Growing …

Human brain is a complex system composed of many components that interact with each
other. A well-designed computational model, usually in the format of partial differential …

Background: Mounting evidence shows that the neuropathological burdens manifest
preference in affecting brain regions during the dynamic progression of Alzheimer's disease …

Amyloid-beta (A) deposition and tau neurofibrillary tangles (tau) are important hallmarks of
Alzheimer's disease (AD). Although converging evidence shows that the interaction between …

A reaction–diffusion Alzheimer's disease model with three delays, which describes the
interaction of β-amyloid deposition, pathologic tau, and neurodegeneration biomarkers, is …

Alzheimer's disease (AD) is characterized by the propagation of tau aggregates throughout
the brain in a prion-like manner. Tremendous efforts have been made to analyze the …

Tremendous efforts have been made to investigate stereotypical patterns of tau aggregates
in Alzheimer's disease (AD), current positron emission tomography (PET) technology lacks …

Background Alzheimer's disease (AD) is a heterogeneous, multifactorial neurodegenerative
disorder characterized by three neurobiological factors beta‐amyloid, pathologic tau, and …

Despite the striking efforts in investigating neurobiological factors behind the acquisition of
beta-amyloid (A), protein tau (T), and neurodegeneration ([N]) biomarkers, the mechanistic …