Structural plasticity of axon initial segment in spinal cord neurons underlies inflammatory pain

Y Caspi, M Mazar, Y Kushnir, Y Mazor, B Katz, S Lev… - Pain, 2023 - journals.lww.com
Physiological or pathology-mediated changes in neuronal activity trigger structural plasticity
of the action potential generation site—the axon initial segment (AIS). These changes affect …

Encoding of inflammatory hyperalgesia in mouse spinal cord

O Barkai, PR Rayi, R Butterman, B Katz, S Lev… - Pain, 2023 - journals.lww.com
Inflammation modifies the input–output properties of peripheral nociceptive neurons such
that the same stimulus produces enhanced nociceptive firing. This increased nociceptive …

Adaptation of pain-related projection neurons in acute but not chronic pain

B Title, E Velasco, NM Engelmayer, PR Rayi, R Yanai… - bioRxiv, 2024 - biorxiv.org
Pain hypersensitivity is associated with increased activity of peripheral and central neurons
along the pain neuroaxis. On the other hand, in other neuronal systems, increased activity …

Encoding of inflammatory hyperalgesia in mice spinal cord

O Barkai, R Butterman, PR Rayi, B Katz, S Lev… - bioRxiv, 2021 - biorxiv.org
Inflammation modifies the input-output properties of peripheral nociceptive neurons, thus
leading to hyperalgesia, a condition in which the perception of noxious heat stimuli is altered …