Klebsiella pneumoniae is among the most common antibiotic-resistant pathogens causing
nosocomial infections. Additionally, it is a leading cause of neonatal sepsis and childhood …

In light of rising antimicrobial resistance and a decreasing number of antibiotics with novel
modes of action, it is of utmost importance to accelerate development of novel treatment …

Objectives Antibacterial drug discovery activities are essential for filling clinical pipelines
with promising clinical candidates. Little information is available about the challenges and …

Background Preclinical murine infection models lack inter-laboratory uniformity,
complicating result comparisons and data reproducibility. The European Innovative …

Background Lack of uniformity in infection models complicates preclinical development. The
COMBINE protocol has standardized the murine neutropenic pneumonia model. Herein we …

Murine pneumonia models for ESKAPE pathogens serve to evaluate novel antibacterials or
to investigate immunological responses. The majority of published models uses intranasal …

The antimicrobial concentration–time profile in humans affects antimicrobial activity, and as
such, it is critical for preclinical infection models to simulate human-like dynamic …

Background Murine pneumonia models play a fundamental role in the preclinical
development of novel compounds seeking an indication for the treatment of pneumonia. It is …

Die zunehmende Unwirksamkeit gängiger Medikamente gegenüber immer mehr
auftretende multiresistente Bakterien erhöht den Bedarf an neuen …