Oligodendrocyte precursor cells (OPCs) are non-neuronal brain cells that give rise to
oligodendrocytes, glia that myelinate the axons of neurons in the brain. Classically known …

Alzheimer's disease (AD) is the leading cause of dementia in older adults. Although AD
progression is characterized by stereotyped accumulation of proteinopathies, the affected …

Adult oligodendrocyte precursor cells (aOPCs), transformed from fetal OPCs, are
idiosyncratic neuroglia of the central nervous system (CNS) that are distinct in many ways …

Background: Patients with Alzheimer's disease (AD) demonstrate progressive white matter
atrophy and myelin loss. Restoring myelin content or preventing demyelination has been …

Oligodendrocyte precursor cells (OPCs) comprise 5–8% of the adult glial cell population and
stand out as the most proliferative cell type in the central nervous system (CNS). OPCs are …

Although the link of white matter to pathophysiology of schizophrenia is documented, loss of
myelin is not detected in patients at the early stages of the disease, suggesting that …

Our prior work examining endogenous repair after spinal cord injury (SCI) in mice revealed
that large numbers of new oligodendrocytes (OLs) are generated in the injured spinal cord …

Oligodendrocyte precursor cells (OPCs) are a heterogeneous multipotent population in the
central nervous system (CNS) that appear during embryogenesis and persist as resident …

Oligodendrocyte progenitor cells (OPC) are the main proliferative cells in the healthy adult
brain. They produce new myelinating oligodendrocytes to ensure physiological myelin …

Background The accumulation of β-amyloid (Aβ) peptides into insoluble plaques is an early
pathological feature of Alzheimer's disease (AD). BACE1 is the sole β-secretase for Aβ …