Betulin is a natural triterpene, usually from birch bark, known for its potential wound-healing
properties. Despite having a wide range of pharmacological targets, no studies have …

Hepatic ischemia-reperfusion injury is a major cause of post-operative hepatic dysfunction
and liver failure after transplantation. Mitochondrial pathways can be either beneficial or …

Non-alcoholic fatty liver disease (NAFLD) is a common chronic hepatic disorder
characterized by hepatic lipid accumulation. This study explored the effect of betulin (BE), a …

The aim of this study was to evaluate the therapeutic effects of chlorogenic acid (CGA) in rats
with advanced alcoholic steatohepatitis. The rats were fed on a high-fat diet and gavaged …

Reduced feed intake during the transition period renders cows unable to meet their energy
needs for maintenance and lactation, leading to a state of negative energy balance. Severe …

Background and objective Pulmonary fibrosis (PF) is a chronic and progressive respiratory
disease representing the final stage of lung inflammatory disorders. Reactive oxygen …

Novel triterpene derivatives were prepared and evaluated in salsolinol (SAL)-and glutamate
(Glu)-induced models of neurodegeneration in neuron-like SH-SY5Y cells. Among the …

Rationale: Obstructive sleep apnea (OSA)–induced endothelial cell (EC) dysfunction
contributes to OSA-related cardiovascular sequelae. The mechanistic basis of endothelial …

Type 2 diabetes is characterized by hyperglycemia and a relative loss of β–cell function. Our
research investigated the antidiabetic potential of betulin, a pentacyclic triterpenoid found …

Alzheimer's disease (AD) is a neurodegenerative disorder that impairs learning and
memory, with high rates of mortality. Birch bark has been traditionally used in the treatment …