Topical drug delivery is an interesting approach to treat skin diseases and to avoid pain and
low patient compliance in cases where a systemic delivery is required. However, the stratum …

Transdermal drug administration has grown in popularity in the pharmaceutical research
community due to its potential to improve drug bioavailability, compliance among patients …

This paper details the systematic approach used to develop a viable clinical prototype of a
therapeutic ultrasound applicator and discusses the rationale and deliberations that led to …

Background: Sustained Acoustic Medicine (SAM) is an emerging, non-invasive, non-
narcotic, home-use ultrasound therapy for the daily treatment of joint pain. The aim of this …

Background Low-intensity ultrasound (LIUS) can reduce pain and improve function in
arthritic joints. Neutrophils are first-line actors in host defense that recruit macrophages …

The primary purpose of this work was to design and implement a compact, battery-powered,
fully wearable applicator for delivering therapeutic low-frequency (20-40kHz), low-intensity …

Man, in his common lore started using the toxin produced by bees, apitoxin, as a topical
medication for rheumatoid arthritis in time immemorial. Systematically subjecting themselves …

The primary purpose of this work was to design and implement a compact, battery-powered,
fully wearable applicator for delivering therapeutic low-frequency (20-40kHz), low-intensity …

The purpose of this thesis was to elucidate the effects of low-frequency (20 kHz), low-
intensity (100 mW/cm 2)(LFLI US) therapeutic ultrasound on macrophage behavior and …

Chronic inflammation is a significant pathological process found in a range of disease
states. Treatments to reduce inflammation in this family of diseases may improve symptoms …