Fucose is a 6-deoxy hexose in the l-configuration found in a large variety of different
organisms. In mammals, fucose is incorporated into N-glycans, O-glycans and glycolipids by …

Aberrant glycosylation is a universal feature of cancer cells that can impact all steps in
tumour progression from malignant transformation to metastasis and immune evasion. One …

Fucosylation is one of the most common modifications involving oligosaccharides on
glycoproteins or glycolipids. Fucosylation comprises the attachment of a fucose residue to N …

The up-regulation of fucosyltransferase 8 (FUT8), the only enzyme catalyzing α1, 6-
fucosylation in mammals, has been observed in several malignant cancers including liver …

Background Core fucosylation (addition of fucose in α-1, 6-linkage to core N-
acetylglucosamine of N-glycans) catalyzed by fucosyltransferase 8 (FUT8) is critical for …

Hematopoietic stem cells (HSCs) residing in specialized niches in the bone marrow are
responsible for the balanced output of multiple short-lived blood cell lineages in steady-state …

Metastatic colorectal cancer (mCRC) is a major cause of cancer-related mortality due to the
absence of effective therapeutics. Thus, it is urgent to discover new drugs for mCRC …

Among the various posttranslational modification reactions, glycosylation is the most
common, and nearly 50% of all known proteins are thought to be glycosylated. In particular …

Glycosylation is one of the most common post‐translational modifications, and
approximately 50% of all proteins are presumed to be glycosylated in eukaryotes. Branched …

BACKGROUND: Cell migration is an essential process in organ homeostasis, in
inflammation, and also in metastasis, the main cause of death from cancer. The extracellular …