Mitochondrial extracellular vesicles, autoimmunity and myocarditis

DN Di Florio, DJ Beetler, EJ McCabe, J Sin… - Frontiers in …, 2024 - frontiersin.org
For many decades viral infections have been suspected as 'triggers' of autoimmune disease,
but mechanisms for how this could occur have been difficult to establish. Recent studies …

Immune modulation through secretory autophagy

A Weigert, L Herhaus - Journal of Cellular Biochemistry, 2024 - Wiley Online Library
Autophagy is a central mechanism of cellular homeostasis through the degradation of a
wide range of cellular constituents. However, recent evidence suggests that autophagy …

Autophagy suppression facilitates macrophage M2 polarization via increased instability of NF-κB pathway in hepatocellular carcinoma

Z Gao, XG Li, SR Feng, JF Chen, K Song… - International …, 2023 - Elsevier
The tumor microenvironment is a highly heterogeneous circumstance composed of multiple
components, while tumor-associated macrophages (TAMs) are major innate immune cells …

Identification of multifunctionality of grass carp (Ctenopharyngodon idella) TBK1 during bacterial infection

H Yu, X Jia, Y Pang, H Niu, B Du, X Xu, J Li - Fish & Shellfish Immunology, 2023 - Elsevier
TBK1 is an atypical IκB kinase family member with a set of functions. It is involved in
congenital immunization and autophagy in mammals. In this study, we reported that grass …

Crosstalk Between Innate Immunity and Autophagy in Viral Myocarditis Leading to Dilated Cardiomyopathy

C Wang, H Luo - Reviews in Medical Virology, 2024 - Wiley Online Library
Viral myocarditis, characterised by inflammation of the heart muscle, presents a significant
challenge to global public health, particularly affecting younger individuals and often …

[HTML][HTML] Common Chemical Plasticizer Di (2-Ethhylhexyl) Phthalate Exposure Exacerbates Coxsackievirus B3 Infection

R Kordbacheh, M Ashley, WD Cutts, TE Keyzer… - Viruses, 2024 - mdpi.com
Di (2-ethhylhexyl) phthalate (DEHP) is a common plastic rubberizer. DEHP leaches from
plastic matrices and is under increasing scrutiny as numerous studies have linked it to …

An insight into codon pattern analysis of autophagy genes associated with virus infection

S Singhal, U Kumar, T Alqahtani… - Current …, 2023 - ingentaconnect.com
Introduction: Apoptosis and autophagy are the two fundamental processes involved in
maintaining homeostasis, and a common stimulus may initiate the processes. Autophagy …

[HTML][HTML] N-Acetylcysteine Inhibits Coxsackievirus B3 Replication by Downregulating Eukaryotic Translation Elongation Factor 1 Alpha 1

Y Wang, T Luan, L Wang, D Feng, Y Dong, S Li… - Viruses, 2024 - mdpi.com
Group B Coxsackieviruses (CVB) are one of the causative pathogens of myocarditis, which
may progress to cardiomyopathy. The pathogenesis of CVB is not fully understood, and …

The complexity of extracellular vesicles: Bridging the gap between cellular communication and neuropathology

S Tam, D Wear, CD Morrone… - Journal of …, 2024 - Wiley Online Library
Brain‐derived extracellular vesicles (EVs) serve a prominent role in maintaining
homeostasis and contributing to pathology in health and disease. This review establishes a …

Porcine sapovirus protease controls the innate immune response and targets TBK1

I Georgana, M Hosmillo, AS Jahun, E Emmott… - Viruses, 2024 - mdpi.com
Human sapoviruses (HuSaVs) and noroviruses are considered the leading cause of acute
gastroenteritis worldwide. While extensive research has focused on noroviruses, our …