Impact of sex and gender on COVID-19 outcomes in Europe
C Gebhard, V Regitz-Zagrosek, HK Neuhauser… - Biology of sex …, 2020 - Springer
Abstract Background Emerging evidence from China suggests that coronavirus disease
2019 (COVID-19) is deadlier for infected men than women with a 2.8% fatality rate being …
2019 (COVID-19) is deadlier for infected men than women with a 2.8% fatality rate being …
Angiotensin-converting enzyme 2: SARS-CoV-2 receptor and regulator of the renin-angiotensin system: celebrating the 20th anniversary of the discovery of ACE2
ACE2 (angiotensin-converting enzyme 2) has a multiplicity of physiological roles that
revolve around its trivalent function: a negative regulator of the renin-angiotensin system …
revolve around its trivalent function: a negative regulator of the renin-angiotensin system …
The pivotal link between ACE2 deficiency and SARS-CoV-2 infection
P Verdecchia, C Cavallini, A Spanevello… - European journal of …, 2020 - Elsevier
Abstract Angiotensin converting enzyme-2 (ACE2) receptors mediate the entry into the cell
of three strains of coronavirus: SARS-CoV, NL63 and SARS-CoV-2. ACE2 receptors are …
of three strains of coronavirus: SARS-CoV, NL63 and SARS-CoV-2. ACE2 receptors are …
Diabetes is a risk factor for the progression and prognosis of COVID‐19
W Guo, M Li, Y Dong, H Zhou, Z Zhang… - Diabetes/metabolism …, 2020 - Wiley Online Library
Backgound To figure out whether diabetes is a risk factor influencing the progression and
prognosis of 2019 novel coronavirus disease (COVID‐19). Methods A total of 174 …
prognosis of 2019 novel coronavirus disease (COVID‐19). Methods A total of 174 …
[HTML][HTML] Why does COVID-19 disproportionately affect older people?
AL Mueller, MS McNamara, DA Sinclair - Aging (albany NY), 2020 - ncbi.nlm.nih.gov
The severity and outcome of coronavirus disease 2019 (COVID-19) largely depends on a
patient's age. Adults over 65 years of age represent 80% of hospitalizations and have a 23 …
patient's age. Adults over 65 years of age represent 80% of hospitalizations and have a 23 …
Organ-specific manifestations of COVID-19 infection
Although COVID-19 presents primarily as a lower respiratory tract infection transmitted via
air droplets, increasing data suggest multiorgan involvement in patients that are infected …
air droplets, increasing data suggest multiorgan involvement in patients that are infected …
Insights to SARS-CoV-2 life cycle, pathophysiology, and rationalized treatments that target COVID-19 clinical complications
Background Gaining further insights into SARS-CoV-2 routes of infection and the underlying
pathobiology of COVID-19 will support the design of rational treatments targeting the life …
pathobiology of COVID-19 will support the design of rational treatments targeting the life …
A mechanistic model and therapeutic interventions for COVID-19 involving a RAS-mediated bradykinin storm
Neither the disease mechanism nor treatments for COVID-19 are currently known. Here, we
present a novel molecular mechanism for COVID-19 that provides therapeutic intervention …
present a novel molecular mechanism for COVID-19 that provides therapeutic intervention …
Thrombosis in COVID‐19
Thrombotic complications are frequent in COVID‐19 and contribute significantly to mortality
and morbidity. We review several mechanisms of hypercoagulability in sepsis that may be …
and morbidity. We review several mechanisms of hypercoagulability in sepsis that may be …
Risk factors of fatal outcome in hospitalized subjects with coronavirus disease 2019 from a nationwide analysis in China
R Chen, W Liang, M Jiang, W Guan, C Zhan, T Wang… - Chest, 2020 - Elsevier
Background The novel coronavirus disease 2019 (COVID-19) has become a global health
emergency. The cumulative number of new confirmed cases and deaths are still increasing …
emergency. The cumulative number of new confirmed cases and deaths are still increasing …