Maternal immune activation (MIA) is critical for imparting neuropathology and altered
behaviors in offspring; however, maternal-fetal immune cell populations have not been …

Multiple sclerosis is characterized by demyelination and neuronal loss caused by
inflammatory cell activation and infiltration into the central nervous system. Macrophage …

Previous studies noted an imbalance in T helper (Th) 17 and regulatory T cells (Tregs) in
experimental autoimmune encephalomyelitis (EAE), a multiple sclerosis animal model …

Type 1 diabetes mellitus is a chronic disease caused by the destruction of pancreatic beta
cells. Based on the hygiene hypothesis, a growing body of evidence suggests a negative …

Objective The immune regulation mechanism induced by parasites may help to develop
new methods to treat inflammatory diseases, such as type 2 diabetes. Different host …

Background Inflammatory bowel disease (IBD) is a chronic and recurrent disease of the
gastrointestinal tract that enhances the chance of developing colorectal cancer. Since …

Background: Dicrocoeliosis is a parasite disease that affects the liver of domestic and wild
ruminants. It is one of the challenges in the livestock industry that causes significant …

Helminth infections and their metabolic products suppress autoimmune demyelinating
disease in Multiple Sclerosis (MS) and in its laboratory model EAE. Helminth infection …

i Univerzita Karlova 1. lékařská fakulta Studijní program: Doktorské studijní programy v
biomedicíně Studijní obor: Biochemie a patobiochemie RNDr. Jan Novák Imunitní odpověď …