Computer simulation offers a fresh approach to traditional medical research that is
particularly well suited to investigating issues related to mechanical ventilation. Patients …

Mechanical ventilation (MV) is a core therapy in the intensive care unit (ICU). Some patients
rely on MV to support breathing. However, it is a difficult therapy to optimise, where inter-and …

Objectives: To evaluate the physiologic effects of applying advice on mechanical ventilation
by an open-loop, physiologic model–based clinical decision support system. Design …

Purpose To assess whether a clinical decision support system (CDSS) suggests PS and FIO
2 maintaining appropriate breathing effort, and minimizing FIO 2. Materials Prospective …

Background Acute respiratory distress syndrome (ARDS) is highly heterogeneous, both in its
clinical presentation and in the patient's physiological responses to changes in mechanical …

Patient-specific spontaneous breathing effort (SB) is common in invasively mechanically
ventilated (MV) adult patients, and especially common in preterm neonates who are not …

This study investigated the clinical and physiological response to use of the BEACON
Caresystem, a bedside open-loop decision support system providing advice to guide …

Ventilatory support, while life saving, can also cause or aggravate lung injury through
several mechanisms which are encompassed within ventilator-associated lung injury (VALI) …

Background The acute respiratory distress syndrome (ARDS) occurs in response to a variety
of insults, and mechanical ventilation is life-saving in this setting, but ventilator-induced lung …

The choice of lung protective ventilation settings for mechanical ventilation has a
considerable impact on patient outcome, yet identifying optimal ventilatory settings for …