Protein methylation, a post-translational modification (PTM), is observed in a wide variety of
cell types from prokaryotes to eukaryotes. With recent and rapid advancements in epigenetic …

There are nine protein arginine methyltransferases (PRMTs) encoded in mammalian
genomes, the protein products of which catalyse three types of arginine methylation …

As a predominant type II protein arginine methyltransferase, PRMT5 plays critical roles in
various normal cellular processes by catalyzing the mono-and symmetrical dimethylation of …

Background Exposure to cigarette smoke (CS) is a major threat to human health worldwide.
It is well established that smoking increases the risk of respiratory diseases, cardiovascular …

Drug resistance remains a major challenge in cancer treatment, necessitating the
development of novel strategies to overcome it. Protein arginine methyltransferases …

The ubiquitous inducible transcription factor NF-κB plays central roles in immune and
inflammatory responses and in tumorigenesis. Complex posttranslational modifications of …

Protein arginine methyltransferases (PRMTs) are known for their ability to catalyze
methylation of specific arginine residues in a wide variety of cellular proteins, which are …

HOXA9 is a homeodomain-containing transcription factor that has an important role in
hematopoietic stem cell expansion and is commonly deregulated in acute leukemias. A …

Abstract Changes in the enzymatic activity of protein arginine methyltransferase (PRMT) 5
have been associated with cancer; however, the protein's role in acute myeloid leukemia …

Protein arginine methyltransferases (PRMTs) are a family of enzymes that can methylate
arginine residues on histones and other proteins. PRMTs play a crucial role in influencing …