The tumor microenvironment (TME) is composed of various cell types embedded in an
altered extracellular matrix (ECM). ECM not only serves as a support for tumor cell but also …

As an alternative to natural extracellular matrix (ECM) macromolecules, cell-adhesion
peptides (CAPs) have had tremendous impact on the design of cell culture platforms …

Angiogenesis, the formation of new blood vessels, is required for many pathologic
processes, including invasive tumor growth as well as physiologic organ/tissue …

Numerous extracellular proteins and glycosaminoglycans (GAG s) undergo limited
enzymatic cleavage resulting in the release of fragments exerting biological activities, which …

Type I and IV collagens are important constituents of the skin. Type I collagen is found in all
dermal layers in high proportion while type IV collagen is localized in the basement …

Background Tumor microenvironment is a complex system composed of a largely altered
extracellular matrix with different cell types that determine angiogenic responses and tumor …

Angiogenesis, the formation of new blood vessels, is required for physiological development
of vertebrates and repair of damaged tissue, but in the pathological setting contributes to …

Canstatin, the noncollagenous domain of collagen type IV α-chains, belongs to a series of
collagen-derived angiogenic inhibitors. We have elucidated the functional receptors and …

The term “matrikines” was coined for designating peptides liberated by partial proteolysis of
extracellular matrix macromolecules, which are able to regulate cell activities. Among these …

Angiogenesis, the creation of neovasculature from native blood vessels, is a prerequisite for
many physiological and pathological processes. Recently, C-terminal tail fragments of …