Functional naphthalene diimides: synthesis, properties, and applications

M Al Kobaisi, SV Bhosale, K Latham… - Chemical …, 2016 - ACS Publications
This comprehensive review surveys developments over the past decade in the field of
naphthalene diimides (NDIs). It explores their application toward: supramolecular chemistry; …

G-quadruplexes and G-quadruplex ligands: targets and tools in antiviral therapy

E Ruggiero, SN Richter - Nucleic acids research, 2018 - academic.oup.com
Abstract G-quadruplexes (G4s) are non-canonical nucleic acids secondary structures that
form within guanine-rich strands of regulatory genomic regions. G4s have been extensively …

Unlocking G-quadruplexes as antiviral targets

A Abiri, M Lavigne, M Rezaei, S Nikzad, P Zare… - Pharmacological …, 2021 - Elsevier
Guanine-rich DNA and RNA sequences can fold into noncanonical nucleic acid structures
called G-quadruplexes (G4s). Since the discovery that these structures may act as scaffolds …

Naphthalene, a versatile platform in medicinal chemistry: sky-high perspective

S Makar, T Saha, SK Singh - European journal of medicinal chemistry, 2019 - Elsevier
Naphthalene, a cytotoxic moiety, is an extensively explored aromatic conjugated system with
applications in various pathophysiological conditions viz. anticancer, antimicrobial, anti …

Far-red fluorescent probes for canonical and non-canonical nucleic acid structures: current progress and future implications

YV Suseela, N Narayanaswamy, S Pratihar… - Chemical Society …, 2018 - pubs.rsc.org
The structural diversity and functional relevance of nucleic acids (NAs), mainly
deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), are indispensable for almost all …

G-quadruplex targeting in the fight against viruses: An update

E Ruggiero, I Zanin, M Terreri, SN Richter - International journal of …, 2021 - mdpi.com
G-quadruplexes (G4s) are noncanonical nucleic acid structures involved in the regulation of
key cellular processes, such as transcription and replication. Since their discovery, G4s have …

SARS-CoV-2 Nsp3 unique domain SUD interacts with guanine quadruplexes and G4-ligands inhibit this interaction

M Lavigne, O Helynck, P Rigolet… - Nucleic acids …, 2021 - academic.oup.com
The multidomain non-structural protein 3 (Nsp3) is the largest protein encoded by
coronavirus (CoV) genomes and several regions of this protein are essential for viral …

Viral G-quadruplexes: New frontiers in virus pathogenesis and antiviral therapy

E Ruggiero, SN Richter - Annual reports in medicinal chemistry, 2020 - Elsevier
Viruses are the most abundant organisms on our planet, affecting all living beings: some of
them are responsible for massive epidemics that concern health, national economies and …

G-quadruplex forming sequences in the genome of all known human viruses: A comprehensive guide

E Lavezzo, M Berselli, I Frasson… - PLoS computational …, 2018 - journals.plos.org
G-quadruplexes are non-canonical nucleic-acid structures that control transcription,
replication, and recombination in organisms. G-quadruplexes are present in eukaryotes …

[HTML][HTML] Targeting G-quadruplexes to achieve antiviral activity

E Ruggiero, SN Richter - Bioorganic & medicinal chemistry letters, 2023 - Elsevier
With the emergence of new viruses in the human population and the fast mutation rates of
existing viruses, new antiviral targets and compounds are needed. Most existing antiviral …