Microfluidics meet cell biology: bridging the gap by validation and application of microscale techniques for cell biological assays

AL Paguirigan, DJ Beebe - Bioessays, 2008 - Wiley Online Library
Microscale techniques have been applied to biological assays for nearly two decades, but
haven't been widely integrated as common tools in biological laboratories. The significant …

From the cellular perspective: exploring differences in the cellular baseline in macroscale and microfluidic cultures

AL Paguirigan, DJ Beebe - Integrative Biology, 2009 - academic.oup.com
Microfluidic devices for cell culture based assays provide new types of engineered
microenvironments and new methods for controlling and quantifying cellular responses to …

Prevention of air bubble formation in a microfluidic perfusion cell culture system using a microscale bubble trap

JH Sung, ML Shuler - Biomedical microdevices, 2009 - Springer
Formation of air bubbles is a serious obstacle to a successful operation of a long-term
microfluidic systems using cell culture. We developed a microscale bubble trap that can be …

Long-term culture and coculture of primary rat and human hepatocytes

M Shulman, Y Nahmias - Epithelial Cell Culture Protocols: Second Edition, 2013 - Springer
The liver is the largest internal organ in mammals, serving a wide spectrum of vital functions.
Loss of liver function due to drug toxicity or viral infection is a major cause of death in the …

[图书][B] Handbook of biodegradable polymers: isolation, synthesis, characterization and applications

A Lendlein, A Sisson - 2011 - books.google.com
A comprehensive overview of biodegradable polymers, covering everything from synthesis,
characterization, and degradation mechanisms while also introducing useful applications …

Periodontal ligament cellular structures engineered with electrospun poly(DL‐lactide‐co‐glycolide) nanofibrous membrane scaffolds

B Inanç, YE Arslan, S Seker, AE Elçin… - Journal of Biomedical …, 2009 - Wiley Online Library
Periodontal tissue engineering is expected to overcome the limitations associated with the
existing regenerative techniques for the treatment of periodontal defects involving alveolar …

Long-term viability and proliferation of alginate-encapsulated 3-D HepG2 aggregates formed in an ultrasound trap

D Bazou, WT Coakley, AJ Hayes, SK Jackson - Toxicology in Vitro, 2008 - Elsevier
We report proof of principle here of a gel encapsulation technique that departs from the
minimum surface area to volume restriction of spherical microcapsules and allows gelation …

Engineering living systems on chips: from cells to human on chips

Y Sei, K Justus, P LeDuc, YT Kim - Microfluidics and nanofluidics, 2014 - Springer
Engineering living systems on chips is an emerging direction with a goal to mimic
physiologically accurate biological functions that can be applied to a diversity of …

Hollow fiber culture accelerates differentiation of Caco-2 cells

X Deng, G Zhang, C Shen, J Yin, Q Meng - Applied microbiology and …, 2013 - Springer
Caco-2 cells usually require 21 days of culture for developing sufficient differentiation in
traditional two-dimensional Transwell culture, deviating far away from the quick …

Enhanced transport capabilities via nanotechnologies: impacting bioefficacy, controlled release strategies, and novel chaperones

T Panagiotou, RJ Fisher - Journal of drug delivery, 2011 - Wiley Online Library
Emerging nanotechnologies have, and will continue to have, a major impact on the
pharmaceutical industry. Their influence on a drug′ s life cycle, inception to delivery, is …