It is estimated that 2% to 3% of the population are currently prescribed systemic or topical
glucocorticoid treatment. The potent anti-inflammatory action of glucocorticoids to deliver …

Vimentin is an intermediate filament protein that plays key roles in integration of cytoskeletal
functions, and therefore in basic cellular processes such as cell division and migration …

The primary adrenal cortical steroid hormones, aldosterone, and the glucocorticoids cortisol
and corticosterone, act through the structurally similar mineralocorticoid (MR) and …

Nearly 100 proteins are known to be regulated by hsp90. Most of these substrates or “client
proteins” are involved in signal transduction, and they are brought into complex with hsp90 …

We used a cellular system to elucidate the molecular determinants of the large immunophilin
FK506-binding proteins (FKBP) 51 and-52 for their action on the glucocorticoid receptor in …

We have identified a new first step in the hormonal activation of the glucocorticoid receptor
(GR). Rather than causing immediate dissociation of the cytoplasmic GR heterocomplex …

The glucocorticoid receptor (GR) belongs to the superfamily of steroid receptors and is an
important regulator of physiological and metabolic processes. In its inactive state, GR is …

Recruitment to activated tyrosine kinase growth factor receptors of Grb2 and p21ras leads to
downstream activation of the kinases Raf, MAPK/Erk kinase (Mek) and, subsequently …

The protein chaperone heat shock protein 90 (Hsp90) is a major regulator of different
transcription factors such as MyoD, a basic helix loop helix (bHLH) protein, and the bHLH …

Steroid hormone receptors (SHRs) are notorious intracellular travellers, transiting among
different cellular compartments as they mature, are subjected to regulation and exert their …