p21Waf1/Cip1/Sdi1 was originally identified as an inhibitor of cyclin-dependent kinases, a
mediator of p53 in growth suppression and a marker of cellular senescence. p21 is required …

TSG-6 expression is upregulated in many cell types in response to a variety of
proinflammatory mediators and growth factors. This protein is detected in several …

Bortezomib therapy has proven successful for the treatment of relapsed/refractory, relapsed,
and newly diagnosed multiple myeloma (MM); however, dose-limiting toxicities and the …

Many solid cancers are known to exhibit a high degree of heterogeneity in their deregulation
of different oncogenic pathways. We sought to identify major oncogenic pathways in gastric …

The cancer stem cell (CSC) hypothesis implicates the development of new therapeutic
approaches to target the CSC population. Characterization of the pathways that regulate …

ABSTRACT Interleukin-6 (IL-6) plays an important role in the development and progression
of inflammatory responses, autoimmune diseases, and cancers. Many viral infections …

The comprehensive characterization of a large number of cancer genomes will eventually
lead to a compendium of genetic alterations in specific cancers. Unfortunately, the number …

The mammalian CIP/KIP family of cyclin-dependent kinase (CDK) inhibitors (CKIs)
comprises three proteins–p21 Cip1/WAF1, p27 Kip1, and p57 Kip2–that bind and inhibit …

The temporal gene expression profile during the entire process of apoptosis and cell cycle
progression in response to p53 in human ovarian cancer cells was explored with cDNA …

In this paper, we review the current literature about the UHRF family that in particular
includes the UHRF1 and UHRF2 genes. Its members play a fundamental role in cell …