• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

Abstract Purpose of Review Stroke is a leading cause of death and disability worldwide. The
annual incidence of new or recurrent stroke is approximately 795,000 cases per year in the …

Objective To investigate the aetiology, subsequent preventive strategies and outcomes of
stroke despite anticoagulation in patients with atrial fibrillation (AF). Methods We analysed …

Anticoagulation substantially reduces the risk of stroke in patients with atrial fibrillation (AF).
However, recent studies have shown that up to 22%–36% of patients on anticoagulation will …

AF contributes to increased stroke risk via various mechanisms, including deranged blood
constituents, vessel wall abnormalities and abnormal blood flow. This excess risk is …

Direct oral anticoagulants are the primary stroke prevention option in patients with atrial
fibrillation. Anticoagulant use before stroke, however, might inhibit clinician comfort with …

Antithrombotic therapy is a key element of secondary prevention in patients who have had
an ischaemic stroke or transient ischaemic attack. However, its use in clinical practice is not …

Background Patients with atrial fibrillation (AF) and oral anticoagulation (OAC) failure may
benefit from left atrial appendage closure (LAAC), however, the evidence is scarce. We …

Background: For reasons poorly understood, strokes frequently occur in patients with atrial
fibrillation (AF) despite oral anticoagulation. Better data are needed to inform randomised …

Coagulation and fibrinolytic system disorders are conditions in which the blood's ability to
clot is impaired, resulting in an increased risk of thrombosis or bleeding. Although these …