Role of the breast cancer resistance protein (BCRP/ABCG2) in drug transport—an update
Q Mao, JD Unadkat - The AAPS journal, 2015 - Springer
The human breast cancer resistance protein (BCRP, gene symbol ABCG2) is an ATP-
binding cassette (ABC) efflux transporter. It was so named because it was initially cloned …
binding cassette (ABC) efflux transporter. It was so named because it was initially cloned …
Overcoming ABC transporter-mediated multidrug resistance: The dual role of tyrosine kinase inhibitors as multitargeting agents
GL Beretta, G Cassinelli, M Pennati, V Zuco… - European journal of …, 2017 - Elsevier
Resistance to conventional and target specific antitumor drugs still remains one of the major
cause of treatment failure and patience death. This condition often involves ATP-binding …
cause of treatment failure and patience death. This condition often involves ATP-binding …
ABCG2 transports anticancer drugs via a closed-to-open switch
BJ Orlando, M Liao - Nature communications, 2020 - nature.com
ABCG2 is an ABC transporter that extrudes a variety of compounds from cells, and presents
an obstacle in treating chemotherapy-resistant cancers. Despite recent structural insights, no …
an obstacle in treating chemotherapy-resistant cancers. Despite recent structural insights, no …
[HTML][HTML] Prediction of drug–ABC-transporter interaction—Recent advances and future challenges
F Montanari, GF Ecker - Advanced drug delivery reviews, 2015 - Elsevier
With the discovery of P-glycoprotein (P-gp), it became evident that ABC-transporters play a
vital role in bioavailability and toxicity of drugs. They prevent intracellular accumulation of …
vital role in bioavailability and toxicity of drugs. They prevent intracellular accumulation of …
Antiseizure medication concentrations during pregnancy: results from the maternal outcomes and neurodevelopmental effects of antiepileptic drugs (MONEAD) study
Importance During pregnancy in women with epilepsy, lower blood concentrations of
antiseizure medications can have adverse clinical consequences. Objective To characterize …
antiseizure medications can have adverse clinical consequences. Objective To characterize …
Cannabis constituents interact at the drug efflux pump BCRP to markedly increase plasma cannabidiolic acid concentrations
LL Anderson, MG Etchart, D Bahceci… - Scientific reports, 2021 - nature.com
Cannabis is a complex mixture of hundreds of bioactive molecules. This provides the
potential for pharmacological interactions between cannabis constituents, a phenomenon …
potential for pharmacological interactions between cannabis constituents, a phenomenon …
Challenges in oral drug delivery of antiretrovirals and the innovative strategies to overcome them
A Sosnik, R Augustine - Advanced drug delivery reviews, 2016 - Elsevier
Abstract Development of novel drug delivery systems (DDS) represents a promising
opportunity to overcome the various bottlenecks associated with the chronic antiretroviral …
opportunity to overcome the various bottlenecks associated with the chronic antiretroviral …
[PDF][PDF] How to overcome ATP-binding cassette drug efflux transporter-mediated drug resistance
AC Jaramillo, F Al Saig, J Cloos, G Jansen… - Cancer Drug Resist, 2018 - f.oaes.cc
Abstract P-glycoprotein (ABCB1), multidrug resistance protein-1 (ABCC1) and breast cancer
resistance protein (ABCG2) belong to the ATP-binding cassette (ABC) superfamily of …
resistance protein (ABCG2) belong to the ATP-binding cassette (ABC) superfamily of …
[引用][C] Molecular pharmacology of ABCG2 and its role in chemoresistance
AE Stacy, PJ Jansson, DR Richardson - Molecular pharmacology, 2013 - ASPET