Elesclomol is an anticancer drug that targets mitochondrial metabolism. In the past,
elesclomol was recognized as an inducer of oxidative stress, but now it has also been found …

Glioblastoma, also referred to as glioblastoma multiforme (GBM), is grade IV astrocytoma
characterized by being fast-growing and the most aggressive brain tumor. In adults, it is the …

The synthesis of mitochondrial OXPHOS complexes is central to cellular metabolism, yet
many molecular details of mitochondrial translation remain elusive. It has been commonly …

The mitoribosome regulates cellular energy production, and its dysfunction is associated
with aging. Inhibition of the mitoribosome can be caused by off-target binding of …

Like living organisms, cancer cells require energy to survive and interact with their
environment. Mitochondria are the main organelles for energy production and cellular …

Targeting the distinct metabolic needs of tumor cells has recently emerged as a promising
strategy for cancer therapy. The heterogeneous, context-dependent nature of cancer cell …

Cancer cells have long been recognized to exhibit unique bioenergetic requirements. The
apoptolidin family of glycomacrolides are distinguished by their selective cytotoxicity towards …

Cancer still ranks as one of the top causes of morbidity and mortality despite recent
improvements in standard chemotherapy, radiotherapy, and surgery. This underlines some …

Mitochondria are the cytoplasmic organelles mostly known as the “electric engine” of the
cells; however, they also play pivotal roles in different biological processes, such as cell …

As an essential micronutrient for humans, the metabolism of copper is fine-tuned by
evolutionarily conserved homeostatic mechanisms. Copper toxicity occurs when its …