The blood–brain barrier: structure, regulation, and drug delivery

D Wu, Q Chen, X Chen, F Han, Z Chen… - Signal Transduction and …, 2023 - nature.com
Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous
system (CNS) from toxins and pathogens in blood. However, the presence of BBB …

[HTML][HTML] Size, shape, charge and “stealthy” surface: Carrier properties affect the drug circulation time in vivo

J Di, X Gao, Y Du, H Zhang, J Gao, A Zheng - Asian journal of …, 2021 - Elsevier
The present review sets out to discuss recent developments of the effects and mechanisms
of carrier properties on their circulation time. For most drugs, sufficient in vivo circulation time …

Biologically modified nanoparticles as theranostic bionanomaterials

J Yang, X Zhang, C Liu, Z Wang, L Deng… - Progress in Materials …, 2021 - Elsevier
Inspired by natural biology, cell membrane-mimetic surface engineering and cell membrane
camouflaging technology have been widely investigated. Notably, the cell membrane …

[HTML][HTML] Cell membrane camouflaged biomimetic nanoparticles: Focusing on tumor theranostics

L Zhu, Y Zhong, S Wu, M Yan, Y Cao, N Mou, G Wang… - Materials Today Bio, 2022 - Elsevier
Nanoparticles (NPs) modified by cell membranes represent an emerging biomimetic
platform that can mimic the innate biological functions resulting from the various cell …

Silicon-containing nanomedicine and biomaterials: materials chemistry, multi-dimensional design, and biomedical application

L Chen, S Zhang, Y Duan, X Song, M Chang… - Chemical Society …, 2024 - pubs.rsc.org
The invention of silica-based bioactive glass in the late 1960s has sparked significant
interest in exploring a wide range of silicon-containing biomaterials from the macroscale to …

Recent trends in cell membrane-cloaked nanoparticles for therapeutic applications

B Choi, W Park, SB Park, WK Rhim, DK Han - Methods, 2020 - Elsevier
Synthetic nanoparticles are extensively utilized in various biomedical engineering fields
because of their unique physicochemical properties. However, their exogenous …

Enhancing Methotrexate Delivery in the Brain by Mesoporous Silica Nanoparticles Functionalized with Cell-Penetrating Peptide using in Vivo and ex Vivo Monitoring

N Shadmani, P Makvandi, M Parsa, A Azadi… - Molecular …, 2023 - ACS Publications
The blood–brain barrier (BBB) acts as a physical/biochemical barrier that protects brain
parenchyma from potential hazards exerted by different xenobiotics found in the systemic …

Latest advances in biomimetic cell membrane-coated and membrane-derived nanovectors for biomedical applications

R Rampado, P Caliceti, M Agostini - Nanomaterials, 2022 - mdpi.com
In the last decades, many nanovectors were developed for different diagnostic or therapeutic
purposes. However, most nanosystems have been designed using a “bottom-up” approach …

[HTML][HTML] Engineering polymer nanoparticles using cell membrane coating technology and their application in cancer treatments: Opportunities and challenges

K Guo, N Xiao, Y Liu, Z Wang, J Tóth, J Gyenis… - Nano Materials …, 2022 - Elsevier
Nanotechnology has revolutionized cancer drug delivery, and recent research continues to
focus on the development of “one-size-fits-all,” ie,“all-in-one” delivery nanovehicles …

[HTML][HTML] Cell-mediated and cell membrane-coated nanoparticles for drug delivery and cancer therapy

S Yaman, U Chintapula, E Rodriguez… - Cancer Drug …, 2020 - ncbi.nlm.nih.gov
Nanotechnology-based drug delivery platforms have been developed over the last two
decades because of their favorable features in terms of improved drug bioavailability and …