Metal complexes have demonstrated significant antitumor activities and platinum complexes
are well established in the clinical application of cancer chemotherapy. However, the …

Cancer immunotherapies targeting adaptive immune checkpoints have substantially
improved patient outcomes across multiple metastatic and treatment-refractory cancer types …

In the tumour microenvironment (TME), immunogenic cell death (ICD) plays a major role in
stimulating the dysfunctional antitumour immune system. Chronic exposure of damage …

The complexity, diversity, and heterogeneity of tumors seriously undermine the therapeutic
potential of treatment. Therefore, the current trend in clinical research has gradually shifted …

Activation of unfolded protein responses (UPRs) in cancer cells undergoing endoplasmic
reticulum (ER) stress promotes survival. However, how UPR in tumor cells impacts anti …

Advanced colorectal cancer is one of the deadliest cancers, with a 5-year survival rate of
only 12% for patients with the metastatic disease. Checkpoint inhibitors, such as the …

Apoptotic cells have long been considered as intrinsically tolerogenic or unable to elicit
immune responses specific for dead cell-associated antigens. However, multiple stimuli can …

Metastasis and recurrence are two unavoidable and intractable problems in cancer therapy,
despite various robust therapeutic approaches. Currently, it seems that immunotherapy is an …

Background Effective maintenance therapies after chemoradiotherapy for lung cancer are
lacking. Our aim was to investigate whether the MUC1 antigen-specific cancer …

Cancer progression is characterized by rapidly proliferating cancer cells that are in need of
increased protein synthesis. Therefore, enhanced endoplasmic reticulum (ER) activity is …