Computational models of various facets of hemostasis and thrombosis have increased
substantially in the last decade. These models have the potential to make predictions that …

Bleeding frequency and severity within clinical categories of hemophilia A are highly
variable and the origin of this variation is unknown. Solving this mystery in coagulation …

Background Biochemical reaction networks are self‐regulated in part due to feedback
activation mechanisms. The tissue factor (TF) pathway of blood coagulation is a complex …

Blood coagulation is a self-repair process regulated by activated platelet surfaces, clotting
factors, and inhibitors. Tissue factor pathway inhibitor (TFPI) is one such inhibitor, well …

Thrombosis under high-shear conditions is mediated by the mechanosensitive blood
glycoprotein von Willebrand factor (vWF). vWF unfolds in response to strong flow gradients …

Thrombosis is one of the main causes of failure in device implantation. Computational
thrombosis simulation is a convenient approach to evaluate the risk of thrombosis for a …

Aortic dissection is a major aortic catastrophe with a high morbidity and mortality risk, and
thoracic endovascular repair (TEVAR) has recently been established as the preferred …

We present the first mathematical model of flow-mediated primary hemostasis in an
extravascular injury which can track the process from initial deposition to occlusion. The …

Subclinical leaflet thrombosis (SLT) is a potentially serious complication of aortic valve
replacement with a bioprosthetic valve in which blood clots form on the replacement valve …

Thrombus formation in blood-contacting medical devices is a major concern in the medical
device industry, limiting the clinical efficacy of these devices. Further, a locally formed clot …