Computational models in cardiology

SA Niederer, J Lumens, NA Trayanova - Nature reviews cardiology, 2019 - nature.com
The treatment of individual patients in cardiology practice increasingly relies on advanced
imaging, genetic screening and devices. As the amount of imaging and other diagnostic …

Next-generation, personalised, model-based critical care medicine: a state-of-the art review of in silico virtual patient models, methods, and cohorts, and how to …

JG Chase, JC Preiser, JL Dickson, A Pironet… - Biomedical engineering …, 2018 - Springer
Critical care, like many healthcare areas, is under a dual assault from significantly
increasing demographic and economic pressures. Intensive care unit (ICU) patients are …

Integrated heart—coupling multiscale and multiphysics models for the simulation of the cardiac function

A Quarteroni, T Lassila, S Rossi… - Computer Methods in …, 2017 - Elsevier
Mathematical modeling of the human heart and its function can expand our understanding of
various cardiac diseases, which remain the most common cause of death in the developed …

[HTML][HTML] A cardiac electromechanical model coupled with a lumped-parameter model for closed-loop blood circulation

F Regazzoni, M Salvador, PC Africa, M Fedele… - Journal of …, 2022 - Elsevier
We propose a novel mathematical and numerical model for cardiac electromechanics,
wherein biophysically detailed core models describe the different physical processes …

Verification of cardiac tissue electrophysiology simulators using an N-version benchmark

SA Niederer, E Kerfoot, AP Benson… - … of the Royal …, 2011 - royalsocietypublishing.org
Ongoing developments in cardiac modelling have resulted, in particular, in the development
of advanced and increasingly complex computational frameworks for simulating cardiac …

Biological research and self-driving labs in deep space supported by artificial intelligence

LM Sanders, RT Scott, JH Yang, AA Qutub… - Nature Machine …, 2023 - nature.com
Abstract Space biology research aims to understand fundamental spaceflight effects on
organisms, develop foundational knowledge to support deep space exploration and …

[HTML][HTML] A machine learning method for real-time numerical simulations of cardiac electromechanics

F Regazzoni, M Salvador, L Dedè… - Computer methods in …, 2022 - Elsevier
We propose a machine learning-based method to build a system of differential equations
that approximates the dynamics of 3D electromechanical models for the human heart …

Calibration of ionic and cellular cardiac electrophysiology models

DG Whittaker, M Clerx, CL Lei… - … Systems Biology and …, 2020 - Wiley Online Library
Cardiac electrophysiology models are among the most mature and well‐studied
mathematical models of biological systems. This maturity is bringing new challenges as …

Modelling the lymphatic system: challenges and opportunities

KN Margaris, RA Black - Journal of the Royal Society …, 2012 - royalsocietypublishing.org
The lymphatic system is a vital part of the circulatory and immune systems, and plays an
important role in homeostasis by controlling extracellular fluid volume and in combating …

[HTML][HTML] Machine learning of multiscale active force generation models for the efficient simulation of cardiac electromechanics

F Regazzoni, L Dedè, A Quarteroni - Computer Methods in Applied …, 2020 - Elsevier
High fidelity (HF) mathematical models describing the generation of active force in the
cardiac muscle tissue typically feature a large number of state variables to capture the …