Despite the long-standing observation of vast neuronal loss in Alzheimer's disease (AD) our
understanding of how and when neurons are eliminated is incomplete. While previous …

Nucleic acid sensing is a critical mechanism by which the immune system monitors for
pathogen invasion. A set of germline‐encoded innate immune receptors detect microbial …

SARS-CoV-2 can cause acute respiratory distress and death in some patients. Although
severe COVID-19 is linked to substantial inflammation, how SARS-CoV-2 triggers …

SARS-CoV-2 causes acute respiratory distress that can progress to multiorgan failure and
death in a minority of patients. Although severe COVID-19 disease is linked to exuberant …

AIM2 is a cytosolic innate immune receptor which recognizes double‐stranded DNA
(dsDNA) released during cellular perturbation and pathogenic assault. AIM2 recognition of …

Recognition of pathogens and altered self must be efficient and highly specific to orchestrate
appropriate responses while limiting excessive inflammation and autoimmune reaction to …

Autoimmune diseases are a group of heterogeneous diseases with diverse clinical
manifestations that can be divided into systemic and organ-specific. The common etiology of …

Pyroptosis is a form of cell death mediated by gasdermin D (GSDMD); it is characterised by
NLRP3 inflammasome activation, caspase activation, cell membrane pore formation, and …

Neurodegenerative diseases are characterized by a dysregulated neuro-glial
microenvironment, culminating in functional deficits resulting from neuronal cell death …

The immune system detects disturbances in homeostasis that occur during infection, sterile
tissue damage and cancer. This initiates immune responses that seek to eliminate the …