In this review, we focus on recent developments in our understanding of nutrient-induced
insulin secretion that challenge a key aspect of the" canonical" model, in which an oxidative …

Diabetes mellitus is one of the most common metabolic diseases in the developed world,
and is associated either with the impaired secretion of insulin or with the resistance of cells …

The α-cells are a part of islets of Langerhans located in the pancreas and are responsible for
glucagon secretion. Calcium signaling is crucial for the regulation of the functions and …

Insufficient insulin secretion is a key component of both type 1 and type 2 diabetes. Since
insulin is released by the islets of Langerhans, obtaining viable and functional islets is …

The individual study of C a 2+ and IP 3 dynamics respectively in a β-cell has yielded limited
information about the cell functions. But the systems biology approaches for such studies …

Islets of Langerhans are multicellular microorgans located in the pancreas that play a central
role in whole-body energy homeostasis. Through secretion of insulin and other hormones …

Mitochondrial metabolism and oxidative respiration are crucial for pancreatic β-cell function
and stimulus secretion coupling. Oxidative phosphorylation (OxPhos) produces ATP and …

The calcium signals regulate the production and secretion of many signaling molecules like
inositol trisphosphate (IP 3) and adenosine triphosphate (ATP) in various cells including …

The standard model for Ca2+ oscillations in insulin-secreting pancreatic β cells centers on
Ca2+ entry through voltage-activated Ca2+ channels. These work in combination with ATP …

Many details of glucose-stimulated intracellular calcium changes in β cells during activation,
activity, and deactivation, as well as their concentration-dependence, remain to be analyzed …