Prior information for population pharmacokinetic and pharmacokinetic/pharmacodynamic analysis: overview and guidance with a focus on the NONMEM PRIOR …
AHXP Chan Kwong, EAM Calvier, D Fabre… - … of Pharmacokinetics and …, 2020 - Springer
Population pharmacokinetic analysis is used to estimate pharmacokinetic parameters and
their variability from concentration data. Due to data sparseness issues, available datasets …
their variability from concentration data. Due to data sparseness issues, available datasets …
Ozonide antimalarial activity in the context of artemisinin-resistant malaria
The ozonides are one of the most advanced drug classes in the antimalarial development
pipeline and were designed to improve on limitations associated with current front-line …
pipeline and were designed to improve on limitations associated with current front-line …
The influence of biological, epidemiological, and treatment factors on the establishment and spread of drug-resistant Plasmodium falciparum
The effectiveness of artemisinin-based combination therapies (ACTs) to treat Plasmodium
falciparum malaria is threatened by resistance. The complex interplay between sources of …
falciparum malaria is threatened by resistance. The complex interplay between sources of …
[HTML][HTML] Safety and PCR monitoring in 161 semi-immune Kenyan adults following controlled human malaria infection
BACKGROUND Naturally acquired immunity to malaria is incompletely understood. We
used controlled human malaria infection (CHMI) to study the impact of past exposure on …
used controlled human malaria infection (CHMI) to study the impact of past exposure on …
Systematic review of artesunate pharmacokinetics: Implication for treatment of resistant malaria
YI Kouakou, M Tod, G Leboucher, A Lavoignat… - International Journal of …, 2019 - Elsevier
Background Artesunate (ART) is an artemisinin derivative used as monotherapy for the
treatment of severe malaria and in combination with a partner drug for non-severe malaria …
treatment of severe malaria and in combination with a partner drug for non-severe malaria …
Malaria parasite clearance: what are we really measuring?
Antimalarial drugs are vital for treating malaria and controlling transmission. Measuring drug
efficacy in the field requires large clinical trials and thus we have identified proxy measures …
efficacy in the field requires large clinical trials and thus we have identified proxy measures …
Insights on inhibition of Plasmodium falciparum plasmepsin I by novel epoxyazadiradione derivatives–molecular docking and comparative molecular field analysis
M Thillainayagam, K Malathi, A Anbarasu… - Journal of …, 2019 - Taylor & Francis
In the present study, we have explored the anti-malarial potential of epoxyazadiradione, the
natural entity extracted from the neem seed oil and its chemical derivatives, against …
natural entity extracted from the neem seed oil and its chemical derivatives, against …
Susceptibility of Plasmodium falciparum to artemisinins and Plasmodium vivax to chloroquine in Phuoc Chien Commune, Ninh Thuan Province, south-central …
NC Phong, M Chavchich, HH Quang, NN San… - Malaria journal, 2019 - Springer
Background Reduced artemisinin susceptibility and artemisinin-based combination therapy
(ACT)-resistance against Plasmodium falciparum and chloroquine (CQ)-resistant P. vivax …
(ACT)-resistance against Plasmodium falciparum and chloroquine (CQ)-resistant P. vivax …
Population pharmacokinetics and pharmacodynamics of the artesunate–mefloquine fixed dose combination for the treatment of uncomplicated falciparum malaria in …
Abstract Background The World Health Organization (WHO) recommends combinations of
an artemisinin derivative plus an anti-malarial drug of longer half-life as treatment options for …
an artemisinin derivative plus an anti-malarial drug of longer half-life as treatment options for …
Population Pharmacokinetics and Pharmacodynamics of Chloroquine in a Plasmodium vivax Volunteer Infection Study
AN Abd‐Rahman, L Marquart… - Clinical …, 2020 - Wiley Online Library
Chloroquine has been used for the treatment of malaria for> 70 years; however, chloroquine
pharmacokinetic (PK) and pharmacodynamic (PD) profile in Plasmodium vivax malaria is …
pharmacokinetic (PK) and pharmacodynamic (PD) profile in Plasmodium vivax malaria is …