Regional differences in the small intestinal proteome of control mice and of mice lacking lysosomal acid lipase
The metabolic contribution of the small intestine (SI) is still unclear despite recent studies
investigating the involvement of single cells in regional differences. Using untargeted …
investigating the involvement of single cells in regional differences. Using untargeted …
Genetic deletion of MMP12 ameliorates cardiometabolic disease by improving insulin sensitivity, systemic inflammation, and atherosclerotic features in mice
M Amor, V Bianco, M Buerger, M Lechleitner… - Cardiovascular …, 2023 - Springer
Abstract Background Matrix metalloproteinase 12 (MMP12) is a macrophage-secreted
protein that is massively upregulated as a pro-inflammatory factor in metabolic and vascular …
protein that is massively upregulated as a pro-inflammatory factor in metabolic and vascular …
Enhanced efficacy of glycoengineered rice cell‐produced trastuzumab
JH Shin, S Oh, MH Jang, SY Lee, C Min… - Plant Biotechnology …, 2024 - Wiley Online Library
For several decades, a plant‐based expression system has been proposed as an alternative
platform for the production of biopharmaceuticals including therapeutic monoclonal …
platform for the production of biopharmaceuticals including therapeutic monoclonal …
Identification of regulatory networks and crosstalk factors in brown adipose tissue and liver of a cold-exposed cardiometabolic mouse model
M Amor, M Diaz, V Bianco, M Svecla, B Schwarz… - Cardiovascular …, 2024 - Springer
Background Activation of brown adipose tissue (BAT) has gained attention due to its ability
to dissipate energy and counteract cardiometabolic diseases (CMDs). Methods This study …
to dissipate energy and counteract cardiometabolic diseases (CMDs). Methods This study …
ASGR1 deficiency improves atherosclerosis but alters liver metabolism in ApoE-/- mice
Abstract The asialoglycoprotein receptor 1 (ASGR1), a multivalent carbohydrate-binding
receptor that primarily is responsible for recognizing and eliminating circulating …
receptor that primarily is responsible for recognizing and eliminating circulating …
ASGR1 deficiency diverts lipids toward adipose tissue but results in liver damage during obesity
Abstract Background Asialoglycoprotein receptor 1 (ASGR1), primarily expressed on
hepatocytes, promotes the clearance and the degradation of glycoproteins, including …
hepatocytes, promotes the clearance and the degradation of glycoproteins, including …
Adding a New Piece to the ASGR1 Puzzle: ANGPTL3
I Garcia-Arcos - Arteriosclerosis, Thrombosis, and Vascular …, 2024 - ahajournals.org
ASGR1 (asialoglycoprotein receptor subunit 1). Individuals carrying these variants showed
decreased levels of plasma non-HDL (high-density lipoprotein)-cholesterol and a lower risk …
decreased levels of plasma non-HDL (high-density lipoprotein)-cholesterol and a lower risk …
Erythropoietin N-glycosylation of Therapeutic Formulations Quantified and Characterized: An Interlab Comparability Study of High-Throughput Methods
R O'Flaherty, M Amez Martín, RA Gardner… - Biomolecules, 2024 - mdpi.com
Recombinant human erythropoietin (EPO) is a biopharmaceutical frequently used in the
treatment of anemia. It is a heavily glycosylated protein with a diverse and complex glycome …
treatment of anemia. It is a heavily glycosylated protein with a diverse and complex glycome …
Whole-Body Physiologically-Based Pharmacokinetic Modeling of GalNAc conjugated siRNAs
EKL Salim, E Sjögren, K Kristensen - 2024 - researchsquare.com
Methods For model development a reference data set was compiled from published studies
on GalNAc-siRNAs with different stabilization chemistry and different target proteins in mice …
on GalNAc-siRNAs with different stabilization chemistry and different target proteins in mice …