Squamous cell carcinomas (SCCs) represent the most frequent human solid tumors and are
a major cause of cancer mortality. These highly heterogeneous tumors arise from closely …

The transcription factor p63 is a member of the p53 gene family that plays a complex role in
cancer due to its involvement in epithelial differentiation, cell cycle arrest and apoptosis …

Hypoxia is a poor-prognosis microenvironmental hallmark of solid tumours, but it is unclear
how it influences the fate of disseminated tumour cells (DTCs) in target organs. Here we …

Triple-negative breast cancer (TNBC) is a highly lethal malignancy, and its clinical
management encounters severe challenges due to its high metastatic propensity and the …

The function of the circadian cycle is to determine the natural 24 h biological rhythm, which
includes physiological, metabolic, and hormonal changes that occur daily in the body. This …

Short p63 isoform, ΔNp63, is crucial for epidermis formation, and it plays a pivotal role in
controlling the turnover of basal keratinocytes by regulating the expression of a subset of …

The impairment of apoptotic pathways represents an efficient mechanism to promote
chemoresistance in cancer cells. We previously showed that in epithelial ovarian cancer …

Disseminated tumor cells (DTCs) undergo a dormant state in the distant metastatic site (s)
before becoming overt metastatic diseases. In prostate cancer (PCa), bone metastasis can …

TP63 is the most ancient member of the p53 gene family. The p53 family comprises three
transcription factors (p53/p63/p73). They share a high degree of homology and similar …

Abstract Most (80%) of the triple-negative breast cancers (TNBCs) express mutant p53
proteins that acquire oncogenic activities including promoting metastasis. We previously …