Cancer is an abnormal state of cells where they undergo uncontrolled proliferation and
produce aggressive malignancies that causes millions of deaths every year. With the new …

Hepatotoxicity of chemotherapeutic agents such as methotrexate, oxaliplatin, and irinotecan
have been well documented and characterized allowing for careful management by …

Urgent intervention is required to improve the 5 year survival rate of pancreatic ductal
adenocarcinoma (PDAC). While the four-drug regimen, FOLFIRINOX (comprising irinotecan …

Modern radiotherapy techniques have enabled high focal doses of radiation to be delivered
to patients with primary and secondary malignancies of the liver. The current clinical practice …

Hepatocyte apoptosis plays important roles in both the removal of external microorganisms
and the occurrence and development of liver diseases. Different conditions, such as virus …

To examine the available literature and summarize what is known about chronic drug‐
induced liver injury. We reviewed PubMed/MEDLINE through March 2015. We developed a …

Human colon microbiota produce a metabolite called urolithin A (URO A) from ellagic acid
and linked compounds, and this metabolite has been demonstrated to have antioxidant, anti …

Clinical application of cyclophosphamide (CP) as an anticancer drug is often limited due to
its toxicity. CP is metabolized mainly in the liver by cytochrome P450 system into acrolein …

Several drugs have been associated with the potential for drug-induced hepatic steatosis
(DIHS) and/or phospholipidosis (DIPL), a lysosomal storage disorder. Drug-induced hepatic …

The off‐target testicular toxicity of the anticancer drug, cisplatin, is a current clinical concern
and worrisome to male cancer patients. Growing evidence has implicated oxidative stress …