Perspective on antigen processing and presentation

ER Unanue - Immunological reviews, 2002 - Wiley Online Library
The phenomenon of antigen processing and presentation and the concept that T cells
recognize peptides resulting from the partial catabolism of proteins, are relatively new …

Elimination of an immunodominant CD4+ T cell epitope in human IFN-β does not result in an in vivo response directed at the subdominant epitope

VP Yeung, J Chang, J Miller, C Barnett… - The Journal of …, 2004 - journals.aai.org
The BALB/cByJ mouse strain displays an immunodominant T cell response directed at the
same CD4+ T cell epitope peptide region in human IFN-β, as detected in a human …

Specificity of peptide selection by antigen-presenting cells homozygous or heterozygous for expression of class II MHC molecules: The lack of competition

A Suri, JJ Walters, O Kanagawa… - Proceedings of the …, 2003 - National Acad Sciences
We isolated and identified naturally processed peptides selected by antigen-presenting cells
homozygous for expression of I-Ag7 or I-Ad class II MHC molecules, or from heterozygous …

DM loss in k haplotype mice reveals isotype-specific chaperone requirements

CH Koonce, G Wutz, EJ Robertson, AB Vogt… - The Journal of …, 2003 - journals.aai.org
DM actions as a class II chaperone promote capture of diverse peptides inside the endocytic
compartment (s). DM mutant cells studied to date express class II bound by class II …

Quantitation of lysozyme peptides bound to class II MHC molecules indicates very large differences in levels of presentation

C Velazquez, R DiPaolo, ER Unanue - The Journal of Immunology, 2001 - journals.aai.org
Knowing the abundance of peptides presented by MHC molecules is a crucial aspect for
understanding T cell activation and tolerance. In this report we determined the relative …

Development of a Chemically Modified Sensor Based on a Pentapeptide and Its Application for Sensitive Detection of Verbascoside in Extra Virgin Olive Oil

IG Munteanu, VR Grădinaru, C Apetrei - International Journal of …, 2022 - mdpi.com
In addition to their antioxidant and antimicrobial action in functional foods, beverages, and in
some dermato-cosmetic products, olive phenolic compounds are also recognized for their …

APCs present Aβk-derived peptides that are autoantigenic to type BT cells

SB Lovitch, JJ Walters, ML Gross… - The Journal of …, 2003 - journals.aai.org
Type BT cells recognize peptide provided exogenously but are ignorant of the same epitope
derived from intracellular processing. In this study, we demonstrate the existence of type BT …

Hindering auxiliary anchors are potent modulators of peptide binding and selection by IAk class II molecules

RR Latek, SJ Petzold… - Proceedings of the …, 2000 - National Acad Sciences
Selection of particular antigen-derived peptides by class II MHC molecules determines the
population of complexes represented on the antigen-presenting cell surface and available …

Chemical identification of a low abundance lysozyme peptide family bound to I-Ak histocompatibility molecules

C Velazquez, I Vidavsky, K van der Drift… - Journal of Biological …, 2002 - ASBMB
The processing by antigen-presenting cells (APC) of the protein hen egg-white lysozyme
(HEL) results in the selection of a number of peptide families by the class II major …

Toward prediction of class II mouse major histocompatibility complex peptide binding affinity: in silico bioinformatic evaluation using partial least squares, a robust …

CK Hattotuwagama, CP Toseland, P Guan… - Journal of chemical …, 2006 - ACS Publications
The accurate identification of T-cell epitopes remains a principal goal of bioinformatics within
immunology. As the immunogenicity of peptide epitopes is dependent on their binding to …