THP-1 is a human monocytic leukemia cell line. After treatment with phorbol esters, THP-1
cells differentiate into macrophage-like cells which mimic native monocyte-derived …

The HL-60 cell line, derived from a single patient with acute promyelocytic leukemia,
provides a unique in vitro model system for studying the cellular and molecular events …

Sazacytidine treatment of mouse C3HlOT1/2 embryonic fibroblasts converts them to
myoblasts at a frequency suggesting alteration of one or only a few closely linked regulatory …

Human sequences related to the transforming gene (v-myc) of avian myelocytomatosis virus
(MC29) are represented by at least one gene and several related sequences that may …

We have identified and molecularly cloned 46 kb of human DNA from chromosome 22 using
a probe specific for the Philadelphia(Ph') translocation breakpoint domain of one chronic …

Six monoclonal antibodies have been isolated from mice immunized with synthetic peptide
immunogens whose sequences are derived from that of the human c-myc gene product …

Cell proliferation and directed cell movement are key events in several normal processes
including embryogenesis and development, responses to injury such as wound repair, and …

Polyoma middle-T antigen is required for viral transformation of cultured cells and for
tumorigenesis in animals. Like many other transforming gene products, middle-T is bound to …

Transcription of c-myc in plasma cells, which are terminally differentiated B cells, is
repressed by plasmacytoma repressor factor. This factor was identified as Blimp-1, known …

Proto-oncogenes may be important in the cellular processes central for the growth and
differentiation of normal cells1, 2. N-myc is a DNA sequence which shares limited homology …