Latrophilin GPCR signaling mediates synapse formation
R Sando, TC Südhof - Elife, 2021 - elifesciences.org
Neural circuit assembly in the brain requires precise establishment of synaptic connections,
but the mechanisms of synapse assembly remain incompletely understood. Latrophilins are …
but the mechanisms of synapse assembly remain incompletely understood. Latrophilins are …
Context-dependent requirement of G protein coupling for Latrophilin-2 in target selection of hippocampal axons
The formation of neural circuits requires extensive interactions of cell-surface proteins to
guide axons to their correct target neurons. Trans-cellular interactions of the adhesion G …
guide axons to their correct target neurons. Trans-cellular interactions of the adhesion G …
Regulation of pulmonary surfactant by the adhesion GPCR GPR116/ADGRF5 requires a tethered agonist-mediated activation mechanism
JP Bridges, C Safina, B Pirard, K Brown, A Filuta… - Elife, 2022 - elifesciences.org
The mechanistic details of the tethered agonist mode of activation for the adhesion GPCR
ADGRF5/GPR116 have not been completely deciphered. We set out to investigate the …
ADGRF5/GPR116 have not been completely deciphered. We set out to investigate the …
Antinociceptive modulation by the adhesion GPCR CIRL promotes mechanosensory signal discrimination
Adhesion-type GPCRs (aGPCRs) participate in a vast range of physiological processes.
Their frequent association with mechanosensitive functions suggests that processing of …
Their frequent association with mechanosensitive functions suggests that processing of …
[HTML][HTML] SNAP-tag-enabled super-resolution imaging reveals constitutive and agonist-dependent trafficking of GPR56 in pancreatic β-cells
Aims/hypothesis. Members of the adhesion G protein-coupled receptor (aGPCR) subfamily
are important actors in metabolic processes, with GPR56 (ADGRG1) emerging as a possible …
are important actors in metabolic processes, with GPR56 (ADGRG1) emerging as a possible …
Membrane-association of EMR2/ADGRE2-NTF is regulated by site-specific N-glycosylation
YS Huang, NY Chiang, GW Chang, HH Lin - Scientific reports, 2018 - nature.com
The evolutionarily conserved adhesion G protein-coupled receptors (aGPCRs) play critical
roles in biological processes as diverse as brain development, cell polarity and innate …
roles in biological processes as diverse as brain development, cell polarity and innate …