Aging is a physiological process mediated by numerous biological and genetic pathways,
which are directly linked to lifespan and are a driving force for all age-related diseases …

Despite its position as the first-line drug for treatment of type 2 diabetes mellitus, the
mechanisms underlying the plasma glucose level-lowering effects of metformin (1, 1 …

Metformin, the world's most prescribed anti-diabetic drug, is also effective in preventing type
2 diabetes in people at high risk,. More than 60% of this effect is attributable to the ability of …

Metformin is the oldest and most commonly used first-line antidiabetic drug because of its
good clinical efficacy, high safety, low cost and easy access. At the same time, in recent …

Metformin, the most widely prescribed medication for obesity-associated type 2 diabetes
(T2D), lowers plasma glucose levels, food intake, and body weight in rodents and humans …

Metformin is the most widely prescribed oral hypoglycemic medication for type 2 diabetes
worldwide. Metformin also retards aging in model organisms and reduces the incidence of …

Objective Metformin modifies the gut microbiome in type 2 diabetes and gastrointestinal
tolerance to metformin could be mediated by the gut microbiome. Methods We enrolled 35 …

Aims The present study tested the hypothesis that metformin treatment may increase
myocardial efficiency (stroke work/myocardial oxygen consumption) in insulin‐resistant …

Introduction Metformin is the first choice drug in the treatment of type 2 diabetes mellitus but
its administration may be linked to gastrointestinal adverse events limiting its use. Objectives …

Metformin (biguanide) is a drug widely used for the treatment of type 2 diabetes. This drug
has been used for 60 years as a highly effective antihyperglycemic agent. The search for the …