Clinical investigations using stem cell products in regenerative medicine are addressing a
wide spectrum of conditions using a variety of stem cell types. To date, there have been few …

The increased risk of disease and decreased capacity to respond to tissue insult in the
setting of aging results from complex changes in homeostatic mechanisms, including the …

Endothelial progenitor cells (EPCs) have been isolated and shown to be effective in animal
models of ischemia, and many groups involved in clinical trials have demonstrated that EPC …

The age-adjusted prevalence of peripheral arterial disease in the US population has been
estimated to approach 12%. The clinical consequences of occlusive peripheral arterial …

After the onset of ischemia, cardiac or skeletal muscle undergoes a continuum of molecular,
cellular, and extracellular responses that determine the function and the remodeling of the …

Background Peripheral vascular disease of the lower extremities comprises a clinical
spectrum that extends from no symptoms to presentation with critical limb ischemia (CLI) …

CD34 is a cell surface antigen expressed in numerous stem/progenitor cells including
hematopoietic stem cells (HSCs) and endothelial progenitor cells (EPCs), which are known …

The age-adjusted prevalence of peripheral arterial disease in the US population was
estimated to approach 12% in 1985, and as the population ages, the overall population …

Background—Critical limb ischemia due to peripheral arterial occlusive disease is
associated with a severely increased morbidity and mortality. There is no effective …

Bone-marrow-derived EPCs (endothelial progenitor cells) play an integral role in the
regulation and protection of the endothelium, as well as new vessel formation. Peripheral …