Twenty years of enamel matrix derivative: the past, the present and the future

RJ Miron, A Sculean, DL Cochran… - Journal of clinical …, 2016 - Wiley Online Library
Abstract Bacground On June 5th, 2015 at Europerio 8, a group of leading experts were
gathered to discuss what has now been 20 years of documented evidence supporting the …

Biomaterials, current strategies, and novel nano-technological approaches for periodontal regeneration

G Iviglia, S Kargozar, F Baino - Journal of functional biomaterials, 2019 - mdpi.com
Periodontal diseases involve injuries to the supporting structures of the tooth and, if left
untreated, can lead to the loss of the tooth. Regenerative periodontal therapies aim, ideally …

A review on endogenous regenerative technology in periodontal regenerative medicine

FM Chen, J Zhang, M Zhang, Y An, F Chen, ZF Wu - Biomaterials, 2010 - Elsevier
Periodontitis is a globally prevalent inflammatory disease that causes the destruction of the
tooth-supporting apparatus and potentially leads to tooth loss. Currently, the methods to …

Application of induced pluripotent stem (iPS) cells in periodontal tissue regeneration

X Duan, Q Tu, J Zhang, J Ye, C Sommer… - Journal of cellular …, 2011 - Wiley Online Library
Tissue engineering provides a new paradigm for periodontal tissue regeneration in which
proper stem cells and effective cellular factors are very important. The objective of this study …

Randomized placebo‐controlled and controlled non‐inferiority phase III trials comparing trafermin, a recombinant human fibroblast growth factor 2, and enamel matrix …

M Kitamura, M Akamatsu, M Kawanami… - Journal of Bone and …, 2016 - academic.oup.com
We investigated the efficacy, safety, and clinical significance of trafermin, a recombinant
human fibroblast growth factor (rhFGF)‐2, for periodontal regeneration in intrabony defects …

From basic science to clinical practice: a review of current periodontal/mucogingival regenerative biomaterials

A De Lauretis, Ø Øvrebø, M Romandini… - Advanced …, 2024 - Wiley Online Library
Periodontitis is a dysbiosis‐driven inflammatory disease affecting the tooth‐supporting
tissues, characterized by their progressive resorption, which can ultimately lead to tooth loss …

Enamel matrix derivative, inflammation and soft tissue wound healing

RJ Miron, M Dard, M Weinreb - Journal of periodontal research, 2015 - Wiley Online Library
Over 15 years have now passed since enamel matrix derivative (EMD) emerged as an agent
capable of periodontal regeneration. Following thorough investigation, evidenced‐based …

Cell‐to‐cell communication–periodontal regeneration

DD Bosshardt, B Stadlinger… - Clinical oral implants …, 2015 - Wiley Online Library
Background Although regenerative treatment options are available, periodontal
regeneration is still regarded as insufficient and unpredictable. Aim This review article …

Structural disorder in proteins brings order to crystal growth in biomineralization

L Kalmar, D Homola, G Varga, P Tompa - Bone, 2012 - Elsevier
Biomineralization, the generation of hard tissues of living organisms, is a process strictly
regulated by hormones, enzymes and a range of regulatory proteins of which several …

Enamel Matrix Derivative: A Review of Cellular Effects In Vitro and a Model of Molecular Arrangement and Functioning

HM Grandin, AC Gemperli, M Dard - Tissue Engineering Part B …, 2012 - liebertpub.com
Background: Enamel matrix derivative (EMD), the active component of Emdogain®, is a
viable option in the treatment of periodontal disease owing to its ability to regenerate lost …