The current review on the function of neutrophil cytosolic factor 1 (NCF1) and induced
reactive oxygen species (ROS) is based on a genetic search for the major genes controlling …

Reactive oxygen species (ROS) and iron play important roles in the innate immune
response. ROS are released by immune cells and are highly reactive and indiscriminately …

One of the most fascinating and exciting periods in my scientific career entailed dissecting
the symbiotic relationship between two membrane transporters, the Nicotinamide adenine …

Background Chronic kidney disease patients are at increased risk of mortality with
cardiovascular diseases and infections as the two leading causes of death for end-stage …

Neutrophils are a specialized subset of white blood cells, which have the ability to store pre-
formed mediators in their cytoplasmic granules. Neutrophils are well-known effector cells …

The main properties of the voltage-gated proton channel (HV1) are described in this review,
along with what is known about how the channel protein structure accomplishes its …

Type I allergies are pathological, type 2 inflammatory immune responses against otherwise
harmless environmental allergens that arise from complex interactions between different …

With a single gene encoding HV1 channel, proton channel diversity is particularly low in
mammals compared to other members of the superfamily of voltage-gated ion channels …

The respiratory burst of phagocytes is essential for human survival. Innate immune defence
against pathogens relies strongly on reactive oxygen species (ROS) production by the …

Introduction Eosinophils have been long implicated in antiparasite immunity and allergic
diseases and, more recently, in regulating adipose tissue homeostasis. The metabolic …