With the rapidly increasing incidence of bladder cancer in China and worldwide, great efforts
have been made to understand the detailed mechanism of bladder cancer tumorigenesis …

In addition to environmental conditions, lifestyle factors, and chemical exposure, aberrant
gene expression and mutations involve in the beginning and development of urological …

Aberrant activation of the epithelial-mesenchymal transition (EMT) pathway drives the
development of solid tumors, which is precisely regulated by core EMT-related transcription …

Ulcerative colitis (UC) is a persistent inflammatory condition affecting the colon's mucosal
lining, leading to chronic bowel inflammation. Despite extensive research, the precise …

The bone morphogenetic protein (BMP) pathway is highly conserved and plays central roles
in health and disease. The quality and quantity of its signaling outputs are regulated at …

Collagen type X α1 chain (COL10A1), a gene encoding the α-1 chain of type X collagen,
serves a key role in conferring tensile strength and structural integrity to tissues …

Nasopharyngeal carcinoma (NPC) is the most common cancer originating in the
nasopharynx. Despite continuous improvement in treatment strategies, recurrence or …

Neuroblastoma (NB) is a pediatric malignancy that arises in the peripheral nervous system,
and the prognosis in the high-risk group remains dismal, despite the breakthroughs in …

Background Tumor necrosis factor receptor-associated factors family genes play a pivotal
role in tumorigenesis and metastasis, functioning as adapters or E3 ubiquitin ligases across …

RNF26 is an important E3 ubiquitin ligase that has been associated with poor prognosis in
bladder cancer. However, the underlying mechanisms of RNF26 in bladder cancer …