Exercise is known to have numerous neuroprotective and cognitive benefits, especially
pertaining to memory and learning related processes. One potential link connecting them is …

Brain‐derived neurotrophic factor (BDNF) is a neurotrophin that is vital to the survival,
growth, and maintenance of neurons in key brain circuits involved in emotional and …

Microtubule associated protein tau is a phosphoprotein which potentially has 80
serine/threonine and 5 tyrosine phosphorylation sites. Normal brain tau contains 2-3 moles …

While the relationship between increased physical activity and cognitive ability has been
conjectured for centuries, only recently have the mechanisms underlying this relationship …

Tau is a microtubule-associated protein with versatile functions in the dynamic assembly of
the neuronal cytoskeleton. Four-repeat (4R-) tauopathies are a group of neurodegenerative …

Investigation of axonal biology in the central nervous system (CNS) is hindered by a lack of
an appropriate in vitro method to probe axons independently from cell bodies. Here we …

We identified axonal defects in mouse models of Alzheimer's disease that preceded known
disease-related pathology by more than a year; we observed similar axonal defects in the …

Alzheimer's disease (AD) is the most common type of dementia and a neurodegenerative
disorder characterized by memory deficits especially forgetting recent information, recall …

Degeneration of basal forebrain cholinergic neurons (BFCNs) contributes to cognitive
dysfunction in Alzheimer's disease (AD) and Down's syndrome (DS). We used Ts65Dn and …

As a principal neuronal microtubule-associated protein, tau has been recognized to play
major roles in promoting microtubule assembly and stabilizing the microtubules and to …