In the first article in this series, Watkins, Krogsgaard-Larsen and Honor4 outlined the
structure-activity requirements at the receptor sites for excitatory amino acids in the …

The σ receptor is a neuronal substrate that binds several psychoactive compounds. These
include cocaine, some steroids, dextromethorphan, phencyclidine (PCP), and …

1. Stable N‐methyl‐D‐aspartic acid (NMDA) receptor‐mediated currents in cultured mouse
hippocampal neurons were evoked by 20 ms pressure pulse applications of L‐aspartate …

Focus on development of very potent and selective a ligands has been intensified during
recent years. Rec-ognition of a binding sites was originally based on the finding that …

ABSTRACT A series of compounds derived from phencyclidine (PCP) was examined in the
sigma receptor and PCP receptor binding assays. The derivatives included compounds …

Sigma receptor (σR) ligands have proven to be useful as cancer diagnostics and anticancer
therapeutics and their ligands have been developed as molecular probes in oncology …

Determinants of antagonism of NMDA and calcium permeable AMPA receptor channels by
organic cations were studied using several homologous series of mono-and dicationic …

receptor ligands represent a new class of potential antipsychotic drugs. This paper presents
the structure-activity relationships leading to novel disubstituted piperidine ligands, which …

The optical antipodes of iV-allyl-N-normetazocine (2; SKF 10047, NANM) were the original
compounds used for the classification of the a receptor as distinct from otherreceptors such …

1 The effects of a series of structurally‐dissimilar σ site ligands were examined on high
voltage‐activated Ca2+ channel activity in two preparations of cultured hippocampal …