Metabolic alterations are a key hallmark of cancer cells, and the augmented synthesis and
use of nucleotide triphosphates is a critical and universal metabolic dependency of cancer …

Methotrexate (MTX) is the first line drug for the treatment of a number of rheumatic and non-
rheumatic disorders. It is currently used as an anchor disease, modifying anti-rheumatic drug …

Methotrexate, a structural analogue of folic acid, is one of the most effective and extensively
used drugs for treating many kinds of cancer or severe and resistant forms of autoimmune …

The treatment and outcomes of patients with rheumatoid arthritis (RA) have been
transformed over the past two decades. Low disease activity and remission are now …

Consenso colombiano de atención, diagnóstico y manejo de la infección por SARS-COV-2/COVID-19
en establecimientos de atención de la salud. Recomendaciones basadas en consenso de …

Rheumatoid arthritis (RA) is a chronic inflammatory disease caused by both genetic and
environmental factors. Smoking has been implicated as one of the most important extrinsic …

During the past 30 years, elucidation of the pathogenesis of rheumatoid arthritis, Crohn's
disease, psoriasis, psoriatic arthritis and ankylosing spondylitis at the cellular and molecular …

Abstract Indoleamine 2, 3-dioxygenase (IDO) is a tryptophan-catabolizing enzyme that,
expressed by different cell types, has regulatory effects on T cells resulting from tryptophan …

Rheumatoid arthritis (RA), a systemic disease, is characterized by a chronic inflammatory
reaction in the synovium of joints and is associated with degeneration of cartilage and …

Methotrexate remains a cornerstone in the treatment of rheumatoid arthritis and other
rheumatic diseases. Folate antagonism is known to contribute to the antiproliferative effects …