The sarcomere is the smallest functional unit of muscle contraction. It is delineated by a
protein-rich structure known as the Z-disk, alternating with M-bands. The Z-disk anchors the …

Abstract Muscle LIM Protein (MLP) has emerged as a key regulator of striated muscle
physiology and pathophysiology. Mutations in cysteine and glycine-rich protein 3 (CSRP3) …

The role and function of a given protein is dependent on its structure. In recent years,
however, numerous studies have highlighted the importance of unstructured, or disordered …

Cardiomyopathies are a severe and chronic cardiovascular burden worldwide, affecting a
large cohort in the general population. Cysteine and glycine-rich protein 3 (CSRP3) is one of …

Cysteine and glycine rich protein 3 (CSRP3) encodes Muscle LIM Protein (MLP), a well-
established disease gene for Hypertrophic Cardiomyopathy (HCM). MLP, in contrast to the …

Detailed assessments of whole heart mechanics are crucial for understanding the
consequences of sarcomere perturbations that lead to cardiomyopathy in mice …

Costameres are signaling hubs at the sarcolemma and important contact points between the
extracellular matrix and cell interior, sensing and transducing biomechanical signals into a …

Background—Mutations in sarcomeric and cytoskeletal proteins are a major cause of
hereditary cardiomyopathies, but our knowledge remains incomplete as to how the genetic …

TTN-1, a titin like protein in Caenorhabditis elegans, is encoded by a single gene and
consists of multiple Ig and fibronectin 3 domains, a protein kinase domain and several …

Muscle lim protein (MLP) has long been regarded as a cytosolic and nuclear muscular
protein. Here, we show that MLP is also expressed in a subpopulation of adult rat dorsal root …