ATP-sensitive K+ (KATP) channels are therapeutic targets for several diseases, including
angina, hypertension, and diabetes. This is because stimulation of KATP channels is …

Ion channels constitute a class of proteins that is ultimately responsible for generating and
orchestrating the electrical signals passing through the thinking brain, the beating heart, and …

Since the start of cardiac surgery in the 1950s, multiple techniques have been used to
protect the heart during the surgical requirement for elective global ischemia (and the still …

Myocardial ischemia and infarction are associated with substantially increased morbidity
and mortality among patients with diabetes mellitus. Although many factors contribute to the …

OBJECTIVE: Depolarizing potassium cardioplegia has been increasingly linked to left
ventricular dysfunction, arrhythmia, and microvascular damage. We tested a new polarizing …

Despite surgical proficiency and innovation driving low mortality rates in cardiac surgery, the
disease severity, comorbidity rate, and operative procedural difficulty have increased …

BACKGROUND: Ex vivo heart perfusion (EVHP) has been proposed as a means to facilitate
the resuscitation of donor hearts after cardiocirculatory death (DCD) and increase the donor …

BACKGROUND: Previous studies showed that nicorandil can reduce coronary events in
patients with coronary artery disease. However, it is unclear whether oral nicorandil …

Elective cardiac arrest during surgery can be achieved by inducing depolarization,
polarization, or influencing calcium mechanisms. Depolarized arrest, induced by elevating …

During cardiac surgery or cardiac transplantation, the heart is subjected to varying periods of
global ischemia. The heart must be protected during this ischemic period to avoid additional …