The etiology of Parkinson's disease (PD) is not well understood but likely to involve both
genetic and environmental factors. Incidence and prevalence estimates vary to a large …

Parkinson's disease (PD) is a common motor disorder of mysterious etiology. It is due to the
progressive degeneration of the dopaminergic neurons of the substantia nigra and is …

Mutations in seven genes are robustly associated with autosomal dominant (SNCA, LRRK2,
EIF4G1, VPS35) or recessive (parkin/PARK2, PINK1, DJ1/PARK7) Parkinson's disease (PD) …

Over the past few years, genetic findings have changed our views on the molecular
pathogenesis of Parkinson disease (PD), as mutations in a growing number of genes have …

Parkinson's disease can be caused by rare familial genetic mutations, but in most cases it is
likely to result from an interaction between multiple genetic and environmental risk factors …

Parkinson's disease (PD) is one of the most common movement disorders caused by the
loss of dopaminergic neuronal cells. The molecular mechanisms underlying neuronal …

Rare mutations in genes originally discovered in multigenerational families have been
associated with increased risk of Parkinson's disease (PD). The involvement of rare variants …

Abstract Grb10-Interacting GYF Protein 2 (GIGYF2) was initially identified through its
interaction with Grb10, an adapter protein that binds activated IGF-I and insulin receptors …

Parkinson's disease (PD) is the second most common neurodegenerative disease, and 5-
10% of the PD cases are genetically inherited as familial PD (FPD). LRRK2 (leucine-rich …

The contribution of the gene of GIGYF2, Grb10-Interacting GYF Protein 2, to Parkinson's
disease (PD) is still ambiguous. To explore the contribution of GIGYF2 to PD at the genetic …