Skeletal muscle plays a critical role in physical function and metabolic health. Muscle is a
highly adaptable tissue that responds to resistance exercise (RE; loading) by …

Loss of skeletal muscle mass is a characteristic feature of various pathologies including
cancer, diabetes, and obesity, as well as being a general feature of ageing. However, the …

Obesity and metabolic disorders such as type 2 diabetes mellitus are accompanied by
increased lipid deposition in adipose and non-adipose tissues including liver, pancreas …

Sarcopenia has been defined as a progressive decline of skeletal muscle mass, strength,
and functions in elderly people. It is accompanied by physical frailty, functional disability …

Age-related muscle dysfunction and sarcopenia are major causes of physical incapacitation
in older adults and currently lack viable treatment strategies. Here we find that sphingolipids …

Sphingolipids in general and ceramides in particular, contribute to pathophysiological
mechanisms by modifying signalling and metabolic pathways. Here, we present the …

Sphingolipids are a family of lipid molecules produced through different pathways in
mammals. Sphingolipids are structural components of membranes, but in response to …

Background Muscle atrophy associated with various pathophysiological conditions
represents a major health problem, because of its contribution to the deterioration of patient …

Improving the health of skeletal muscle is an important component of obesity treatment.
Apart from allowing for physical activity, skeletal muscle tissue is fundamental for the …

Sphingolipids represent one of the major classes of eukaryotic lipids. They play an essential
structural role, especially in cell membranes where they also possess signaling properties …