Highlights•Precision medicine is necessary to treat multiple facets of osteoarthritis.•Disease-
modifying osteoarthritis drugs (DMOADs) and drug delivery systems (DDSs) are …

Drug delivery for osteoarthritis (OA) treatment is a continuous challenge because of their
poor bioavailability and rapid clearance in joints. Intra-articular (IA) drug delivery is a …

Biodegradable polymers have met with an increasing demand in medical usage over the
last decades. One of such polymers is poly (ε-caprolactone)(PCL), which is a polyester that …

Long-acting injectables are considered one of the most promising therapeutic strategies for
the treatment of chronic diseases as they can afford improved therapeutic efficacy, safety …

Abstract Treatment of osteoarthritis (OA) by administration of corticosteroids is a commonly
used method in clinics using anti-inflammatory medicine. Oral administration or intra …

Osteoarthritis (OA) is a progressive and degenerative disease, which is no longer confined
to the elderly. So far, current treatments are limited to symptom relief, and no valid OA …

Irritant contact dermatitis (ICD) is an inflammatory skin condition characterized by severe
eczematous lesions. Nanoparticulate drug delivery is the most predominant way to improve …

Chemo-photothermal therapy shows great potential for inhibiting tumor growth. However,
achieving maximal chemo-photothermal synergistic efficacy is challenging because of the …

The management of osteoarthritis (OA) is a clinical challenge due to the particular avascular,
dense, and occluded tissue structure. Despite numerous clinical reports and animal studies …

Inflammation that is not resolved in due course becomes a chronic disease. The treatment of
chronic inflammatory diseases involves a long-term use of anti-inflammatory drugs such as …