All organisms suffer double‐strand breaks (DSBs) in their DNA as a result of exposure to
ionizing radiation. DSBs can also form when replication forks encounter DNA lesions or …

How DNA is organized in three dimensions inside the cell nucleus and how this affects the
ways in which cells access, read and interpret genetic information are among the longest …

Proteins are essential agents of biological processes. To date, large-scale profiling of cell
line collections including the Cancer Cell Line Encyclopedia (CCLE) has focused primarily …

Eukaryotic genomes are packaged into a 3-dimensional structure in the nucleus. Current
methods for studying genome-wide structure are based on proximity ligation. However, this …

In eukaryotes transcriptional regulation often involves multiple long-range elements and is
influenced by the genomic environment. A prime example of this concerns the mouse X …

The architecture of interphase chromosomes is important for the regulation of gene
expression and genome maintenance. Chromosomes are linearly segmented into hundreds …

Transcriptional regulation in eukaryotes occurs within a chromatin setting, and is strongly
influenced by the post-translational modification of histones, the building blocks of …

The tissue-specific pattern of mRNA expression can indicate important clues about gene
function. High-density oligonucleotide arrays offer the opportunity to examine patterns of …

CTCF-binding locations represent regulatory sequences that are highly constrained over the
course of evolution. To gain insight into how these DNA elements are conserved and spread …

High-throughput technologies have led to the rapid generation of large-scale datasets about
genes and gene products. These technologies have also shifted our research focus from …